Abstract Title:
Anti-tumor promoting effect of glycosides from Prunus persica seeds.
Abstract Source:
Abstract:
Four minor components, along with the major cyanogenic glycosides, amygdalin
and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin),
and characterized as mandelic acid glycosides (beta-gentiobioside and
beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and
beta-D-glucoside). The anti-tumor promoting activity of these compounds was
examined in both in vitro and in vivo assays. All of the compounds significantly
inhibited the Epstein-Barr virus early antigen activation induced by tumor
promoter. In addition, they produced a delay of two-stage carcinogenesis on
mouse skin that was comparable in potency to (-)-epigallocatechin gallate from
green tea. Structure-activity relationships indicated that a substituent at the
benzylic position with glycosidic linkage affected the in vitro and in vivo
activities with an order of enhancing potency, CN<COOH<H.
Article
Published Date : Feb 01, 2003
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