Wednesday, March 2, 2016

Amygdalin in Bitter almond could inhibit colon cancer growth

Abstract Title:
Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells
Abstract Source:
World J Gastroenterol. 2005 Sep 7;11(33):5156-61. PMID: 16127745

Abstract Author(s):
Hae-Jeong Park, Seo-Hyun Yoon, Long-Shan Han, Long-Tai Zheng, Kyung-Hee Jung, Yoon-Kyung Uhm, Je-Hyun Lee, Ji-Seon Jeong, Woo-Sang Joo, Sung-Vin Yim, Joo-Ho Chung, Seon-Pyo Hong

AIM: The genes were divided into seven categories according to biological function; apoptosis-related, immune response-related, signal transduction-related, cell cycle-related, cell growth-related, stress response-related and transcription-related genes. METHODS: We compared the gene expression profiles of SNU-C4 cells between amygdalin-treated (5 mg/mL, 24 h) and non-treated groups using cDNA microarray analysis. We selected genes downregulated in cDNA microarray and investigated mRNA levels of the genes by RT-PCR. RESULTS: Microarray showed that amygdalin downregulated especially genes belonging to cell cycle category: exonuclease 1 (EXO1), ATP-binding cassette, sub-family F, member 2 (ABCF2), MRE11 meiotic recombination 11 homolog A (MRE11A), topoisomerase (DNA) I (TOP1), and FK506 binding protein 12-rapamycin-associated protein 1 (FRAP1). RT-PCR analysis revealed that mRNA levels of these genes were also decreased by amygdalin treatment in SNU-C4 human colon cancer cells. CONCLUSION: These results suggest that amygdalin have an anticancer effect via downregulation of cell cycle-related genes in SNU-C4 human colon cancer cells, and might be used for therapeutic anticancer drug.

Study Type : In Vitro Study

Other study are also favoring for many natural ingredients that could inhibit cancer groth-

See comment in PubMed Commons below
2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.

Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway.


The results indicate that the molecular mechanism underlying the antitumor effect of quercetin in SW480 colon cancer cells is related to the inhibition of expression of cyclin D(1) and survivin as well as the Wnt/beta-catenin signaling pathway. Therefore, the Wnt/beta-catenin signaling pathway could be qualified as one of the promising targets for innovative treatment strategies of colorectal cancer.

Bitter almonds and bladder cancer
NIH research
Anti cancer Quercetin

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